Having less then three meals a day can cause health issues such as an increase in bad cholesterol. "The changes in cardiovascular disease risk factors occurred despite the fact that the one- mealers saw slight decreases in their weight and fat mass in comparison to when they were three-mealers." "Further analysis of the study group showed that when the volunteers were one-mealers, they had higher morning fasting blood sugar levels, higher and more sustained elevations in blood sugar concentrations, and a delayed response to the body's insulin, compared to when they were "three-mealers."

Source: Science Daily